Regulation and boundary between cosmetic, medical device and medicine In Europe, topical peptides fall under three distinct regulatory frameworks according to their claim and mechanism: Cosmetic (EC Regulation 1223/2009) Surface cutaneous action, beauty and hygiene claims No therapeutic claim authorised Product information file (PIF), safety evaluation Examples: Matrixyl, Argireline, Pal-GHK in anti-ageing serums Medical device (EU Regulation 2017/745) Main physical/mechanical action, medical claim Classes I, IIa, IIb, III according to risk CE marking mandatory, notified bodies for class IIa+ Example: GHK-Cu dressings for wound healing Medicine (Directive 2001/83/EC) Explicit therapeutic claim, pharmacological action MA mandatory (EMA or national agencies), phase I-III clinical trials Example: Afamelanotide for erythropoietic protoporphyria (MA 2014) This segmentation has direct implications for research : a molecule can change regulatory status according to its final formulation and claims
METHYL B 12 This vitamin has shown improvements in executive functions can occur such as: Awareness Cognition Appropriateness Eye contact Responsiveness There is also normalization in behaviours, social interaction and promotion of speech and language such as: Spontaneous language More complex sentences Increased vocabulary In addition, improvements in socialization, understanding and expressing emotion are also noted, such as: Initiation and interactive play Understanding and feeling emotions Affection and tolerance to touch The function of B12 in the body B12 (cobalamin) is a vitamin family where only 1 form (methylcobalamin) is involved in critical methylation pathways in the body
Numerous peptide growth factors are supposed to influence angiogenesis, and thereby wound healing and tissue regeneration
The research confirms that GHK-Cu can effectively tighten loose skin and help make thin, fragile skin appear thicker and more resilient
S.SchachterM.SmitsP.HughesA
Maroon developed research interests in the use of omega-3 fatty acids as a safe and natural alternative to non-steroidal anti-inflammatory drugs (NSAIDs) in treating neck and low-back pain in patients with disc and arthritic causes
